Thermal Analysis in Pharmaceutical Industry

Thermal analysis is a well-proven technique that offers benefits for various applications in the pharmaceutical sector. As the industry has embraced this technology, techniques and methods dedicated to testing pharmaceutical products – such as active ingredients, excipients and packaging materials – have been developed.

Thermal analysis is widely used in the pharmaceutical industry for a range of applications. This guide is designed to support thermal analysis users with real world examples. It describes how different techniques – in particular differential scanning calorimetry (DSC) and thermogravimetry – can be used to investigate polymorphism and pseudopolymorphism, stability, interactions, purity and packaging materials. It covers:

  • Introduction to thermal analysis techniques
  • What thermal analysis can do for pharmaceuticals
  • Thermal analysis techniques and their applications

• Examples:

  • Polymorphism – sulfapyridine
  •  Stability – acetylsalicylic acid
  • Characterization/identification – vanillin
  • Characterization/identification – polyethylene glycol (PEG)
  • Purity – phenacetin and para-aminobenzoic acid (PABA)
  • Measurement errors and measurement uncertainty
  •  Method development
  • Instrument calibration and adjustment
  • Crucibles, accessories and reference materials