Thermal analysis is a well-proven technique that offers benefits for various applications in the pharmaceutical sector. As the industry has embraced this technology, techniques and methods dedicated to testing pharmaceutical products – such as active ingredients, excipients and packaging materials – have been developed.
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Thermal analysis is widely used in the pharmaceutical industry for a range of applications. This guide is designed to support thermal analysis users with real world examples. It describes how different techniques – in particular differential scanning calorimetry (DSC) and thermogravimetry – can be used to investigate polymorphism and pseudopolymorphism, stability, interactions, purity and packaging materials. It covers:
- Introduction to thermal analysis techniques
- What thermal analysis can do for pharmaceuticals
- Thermal analysis techniques and their applications
• Examples:
- Polymorphism – sulfapyridine
- Stability – acetylsalicylic acid
- Characterization/identification – vanillin
- Characterization/identification – polyethylene glycol (PEG)
- Purity – phenacetin and para-aminobenzoic acid (PABA)
- Measurement errors and measurement uncertainty
- Method development
- Instrument calibration and adjustment
- Crucibles, accessories and reference materials