Real-time Microbial Detection In Pharmaceutical Waters

On-line conductivity and TOC sensors can be used to measure Purified Water and Water for Injection. But bioburden measurement for these critical waters is almost always done using retrospective and time-consuming growth-based laboratory methods. This has been due to a lack of on-line microbial contamination monitors. Laser-induced fluorescence, as used in the 7000RMS analyzer, is a bioburden measurement technique that provides instant notification of excursions, leading to improved product quality, greater process understanding, risk reduction and lower operating costs.

This white paper explains the recent developments in spectroscopic technology which now offers accurate, continuous, on-line determination of microbial and inert particle contamination in pharmaceutical water systems.