Particle Characterization – Small Scale Lab Reactors to Full Scale Production Pipelines

Particles, crystals and droplets often present challenges for scientists and engineers tasked with optimizing product quality and process efficiency. Effective characterization of particle properties, such as size, shape and count, allows issues with downstream processing to be overcome, improving workflow efficiency and product quality.

Historically, particles have been characterized using offline particle size analyzers, for example, laser diffraction or sieving. Over time, technologies have emerged that determine particle size and count in real time, enabling in-process measurements that deliver continuous information about particle behavior under changing process conditions. This has allowed scientists to understand and optimize difficult processes using evidence-based methods. Crystallization is a particularly challenging particle formation process, where the particle size after isolation can dramatically affect all downstream processing operations.

This white paper introduces some of the most common in-process particle measurement approaches, and describes how they can be used for the effective delivery of high-quality particle products. With a complete particle engineering toolbox, including in-line and offline analytical techniques, scientists can:

  • design particles with the desired physical properties
  • obtain evidence to identify the root causes of failures
  • document process understanding and demonstrate process control
  •  use data to support confident transfer from lab to plant