Literature Review: Chemical Reaction Profiling

Scientists in academic and industrial laboratories working on synthesizing new chemical entities use in situ FTIR spectroscopy to more effectively obtain reaction rate information and to deduce reaction mechanisms. The value of this technique is highlighted by the plethora of publications citing its use in chemical synthesis research.

Understanding the kinetics and mechanisms of the individual reactions in a new synthetic route is important to help advance novel chemistries. In situ FTIR spectroscopy is often used by scientists synthesizing new chemical entities, as it provides valuable information on reaction rates and mechanisms. The popularity of this technique is well evidenced by the thousands of articles and citations over the past three decades that reference the use of in situ FTIR spectroscopy for synthesis research in chemistry.

The ability to observe molecular changes occurring in a reaction as a function of time provides scientists with rapid insight, including:

  • Kinetic information
  • Structural data
  • Mechanistic understanding
  • Catalytic cycle characterization
This white paper reviews some recent research using this powerful technique to better understand chemical synthesis, including 20 examples from academic institutions that rely on in situ FTIR to comprehensively understand their reaction chemistries.