White Paper: Innovative Techniques to Synthesize Breakthrough Molecules

Scientists' capacity to evaluate a wide range of synthesis conditions is often constrained by the inability of traditional synthesis set-ups to control key parameters, such as temperature, dosing rate, stirring efficiency and pH. To overcome these limitations, researchers are exploring new possibilities for control, optimization and reporting of critical process conditions.

Traditional synthesis methods often lack the control capabilities necessary to explore a wide range of experimental conditions, limiting scientists’ ability to discover new synthetic pathways. This lack of control can hinder the pace of development by preventing the evaluation of critical process parameters – such as temperature, dosing rate, stirring speed and pH.

Conventional equipment set-ups – heating mantles, ice baths and cryostats, plus standalone dosing funnels and stirrer motors – have limited temperature ranges and offer poor control of other parameters. They are also manually intensive to use and do not easily capture and report real-time data for process optimization or regulatory purposes.

This white paper discusses how technological advances have opened up new possibilities for the control, optimization and reporting of critical process conditions, with a focus on four pharmaceutical case studies:

  • Identifying the ideal operating conditions for a successful triflation reaction
  • Parameter control to avoid impurity formation during a guanidine reaction
  • Central composite Design of Experiment (DoE) for guanidine reaction scale-up
  • Inline reaction rate meter tracking of a two-step lithium borohydride reduction