Crystallization in Process Chemistry

Applying Simple PAT Tools

 In process chemistry, crystallization is a common step used during the synthesis of organic compounds to isolate and purify the desired product, and chemists now spend more time developing better crystallization processes. Intermediate synthesis steps can be improved with crystallization for impurity rejection and more efficient downstream filtration. Also, the final synthesis step can be optimized with crystallization of the active ingredient under strict regulatory guidelines and with the desired bioavailability.

By adopting simple Process Analytical Technologies (PAT), new insights into crystallization can be found in process chemistry - without requiring a high level of expertise. One PAT technology, real-time microscopy, provides high quality images and videos of crystals and crystal structures inline as process conditions are changing.

This white paper discusses how to apply simple PAT tools to crystallization in process chemistry to:

  • Identify Polymorphs During Crystallization Development
  • Recognize and Address Oiling Out (Liquid-Liquid Phase Separation)
  • Measure the Influence of Cooling Rate on Crystal Size and Shape
  • Understand Factors Affecting Crystal Size, Shape, and Structure